As compared with conventional vaccine production systems, plant-made vaccines are said to enjoy a range of advantages including cost of production and ease of storage for distribution in developing countries. In this article, we introduce the science of PMV production, and address ethical issues associated with development and clinical testing of PMVs within three interrelated domains: PMVs as transgenic plants; PMVs as clinical research materials; and PMVs as agents of global health. We present three conclusions: first, while many of the (...) ethical issues raised by PMVs are familiar, PMVs add a new dimension to old issues, and raise some novel issues for ethicists and policy-makers; secondly, it is premature to promise broad applicability of PMVs across the developing world without having demonstrated their feasibility; thirdly, in particular, proponents of PMVs as a solution to global health problems must, as a condition of the ethical conduct of their research, define the commercial feasibility of PMVs for distribution in the developing world. (shrink)

This paper establishes six critical elements – history, political structures, religion, social customs, civil society openness, and level of economic development –needed to understand the context of corporate social responsibility in other countries and other cultures. Labor conditions in China are used as a case study.

Consumers have the power to influence the social performance of corporations, but in the United States this power has gone largely unused. And too little attention has been paid to consumer issues by IABS scholars. To better understand why and when consumer boycotts are either effective or successful, this paper studies the reaction to two oil industry incidents: the Exxon Valdez oil spill in Alaska and the Shell Oil Brent Spar controversy. Five ingredients are identified as important to the understanding (...) of consumer activism: culture, context, cause, challenge, and charisma. (shrink)

This paper explores the social, legal, and political issues Wal-Mart faces in each of the three North American countries and suggests reasons for the quite significant differences. It also issues a call to Business and Society scholars to add prescriptive work to the already large body of descriptive work that has been collected.

The paper compares the business-government-society relationship between China and the U.S. through the analysis of three cases: the tainted milk scandal in China, the beef recall in the U.S., and the peanut scandal in the U.S.

The paper compares the business-government-society relationship between China and the U.S. through the analysis of three cases: the tainted milk scandal in China, the beef recall in the U.S., and the peanut scandal in the U.S.

The Theory of Knowledge: A Thematic Introduction explains the main ideas and problems of contemporary epistemology while avoiding technical detail. Comprehensive and rich in illustrations and examples, it highlights contemporary debates over the definition, sources, and limits of human knowledge, and covers major topics including the nature of belief, theories of truth, epistemic justification, the Gettier problem, skepticism, and epistemic rationality. Its discussions identify important connections between traditional epistemological questions and cognitive science, the history of science, the sociology of knowledge, (...) and cross-cultural studies. The book culminates with a focus on questions regarding epistemological method and an examination of the roots of contemporary analytic approaches to epistemology. The authors defend a distinctive position regarding epistemological method, called broad explanationism, that incorporates some insights from naturalism in epistemology. The volume is enhanced by a glossary of important epistemological terms and suggestions for further reading. Easily accessible to beginning students in philosophy, The Theory of Knowledge serves as an ideal text for courses in the theory of knowledge and will also appeal to general readers interested in philosophy. (shrink)

Evidence shows that changes in the architecture, design, and decor of health care facilities can improve patient care and in the long run reduce expenses. These essays detail the state of the research, look inside two hospitals that put some of these innovations into practice, and consider how design fits into the moral mission ofhealth care.

Recent progress in artificial intelligence (AI) has drawn attention to the technology’s transformative potential, including what some see as its prospects for causing large-scale harm. We review two influential arguments purporting to show how AI could pose catastrophic risks. The first argument — the Problem of Power-Seeking — claims that, under certain assumptions, advanced AI systems are likely to engage in dangerous power-seeking behavior in pursuit of their goals. We review reasons for thinking that AI systems might seek power, that (...) they might obtain it, that this could lead to catastrophe, and that we might build and deploy such systems anyway. The second argument claims that the development of human-level AI will unlock rapid further progress, culminating in AI systems far more capable than any human — this is the Singularity Hypothesis. Power-seeking behavior on the part of such systems might be particularly dangerous. We discuss a variety of objections to both arguments and conclude by assessing the state of the debate. (shrink)

As in other societies, medical professionalism in the Peoples’ Republic of China has been rapidly evolving. One of the major events in this process was the endorsement in 2005 of the document, “Medical Professionalism in the New Millennium: A Physician Charter,” by the Chinese Medical Doctor Association (hereafter, the Charter). More recently, a national survey, the first on such a large scale, was conducted on Chinese physicians’ attitudes toward the fundamental principles and core commitments put forward in the Charter. Based (...) on empirical findings from that study and comparing them to the published results of a similar American survey, the authors offer an in-depth interpretation of significant cross-cultural differences and important transcultural commonalities. The broader historical, socio-economic, and ethical issues relating to salient Chinese cultural practices such as family consent, familism (the custom of deferring decisions to family members), and the withholding of medical information, as well as controversial topics such as not respecting patients’ autonomy, are examined. The Chinese Survey found that Chinese physicians supported the principles of the Charter in general. Here we argue that Chinese culture and traditional medical ethics are broadly compatible with the moral commitments demanded by modern medical professionalism. Methodologically and theoretically—recognizing the problems inherent in the hoary but still popular habit of dichotomizing cultures and in relativism—a transcultural approach is adopted that gives greater (due) weight to the internal moral diversity present within every culture, the common ground shared by different cultures, and the primacy of morality. Genuine crosscultural dialogue, including a constructive Chinese-American dialogue in the area of medical professionalism, is not only possible, but necessary. (shrink)

Under the impressive editorship of Warren Samuels et al, this book addresses the state of the history of economic thought today. An important contribution to the study of the history of economics, this eagerly-awaited book will develop an unsurprisingly large following.

ObjectiveOverweight and obesity [body mass index ≥ 25 kg/m2] are associated with poorer prognosis among women with breast cancer, and weight gain is common during treatment. Symptoms of depression and anxiety are also highly prevalent in women with breast cancer and may be exacerbated by post-diagnosis weight gain. Altered brain function may underlie psychological distress. Thus, this secondary analysis examined the relationship between BMI, psychological health, and resting state functional connectivity among women with breast cancer.MethodsThe sample included 34 post-menopausal women (...) newly diagnosed with Stage 0-IIa breast cancer who were enrolled in a 6-month randomized controlled trial of aerobic exercise vs. usual care. At baseline prior to randomization, whole-brain analyses were conducted to evaluate the relationship between BMI and seed-to-voxel rsFC of the hippocampus and amygdala. Connectivity values from significant clusters were then extracted and examined as predictors of self-reported depression and anxiety.ResultsMean BMI was in the obese range. For both seeds examined, higher BMI was associated with lower rsFC with regions of prefrontal cortex, including ventrolateral PFC, dorsolateral PFC, and superior frontal gyrus. Hippocampal connectivity with the vlPFC was negatively correlated with self-reported anxiety.ConclusionHigher BMI was associated with lower hippocampal and amygdala connectivity to regions of PFC implicated in cognitive control and emotion regulation. BMI-related differences in hippocampal and amygdala connectivity following a recent breast cancer diagnosis may relate to future worsening of psychological functioning during treatment and remission. Additional longitudinal research exploring this hypothesis is warranted. (shrink)

Background Informed consent is an integral component of good medical practice. Many researchers have investigated measures to improve the quality of informed consent, but it is not clear which techniques work best and why. To address this problem, we propose developing a core outcome set to evaluate interventions designed to improve the consent process for surgery in adult patients with capacity. Part of this process involves reviewing existing research that has reported what is important to patients and doctors in the (...) informed consent process. Methods This qualitative synthesis comprises four phases: identification of published papers and determining their relevance; appraisal of the quality of the papers; identification and summary of the key findings from each paper while determining the definitiveness of each finding against the primary data; comparison of key themes between papers such that findings are linked across studies. Results Searches of bibliographic databases returned 11,073 titles. Of these, 16 studies met the inclusion criteria. Studies were published between 1996 and 2016 and included a total of 367 patients and 74 health care providers. Thirteen studies collected data using in-depth interviews and constant comparison was the most common means of qualitative analysis. A total of 94 findings were extracted from the primary papers and divided into 17 categories and ultimately 6 synthesised findings related to: patient characteristics, knowledge, communication, the model patient, trust and decision making. Conclusions This qualitative meta-aggregation is the first to examine the issue of informed consent for surgery. It has revealed several outcomes deemed important to capture by patients and clinicians when evaluating the quality of a consent process. Some of these outcomes have not been examined previously in research comparing methods for informed consent. This review is an important step in the development of a COS to evaluate interventions designed to improve the consent process for surgery. Registration The study protocol was registered on the international prospective register for systematic reviews. (shrink)

What is the ontology of collective action? I have in mind three connected questions. 1. Do the truth conditions of action sentences about groups require there to be group agents over and above individual agents? 2. Is there a difference, in this connection, between action sentences about informal groups that use plural noun phrases, such as ‘We pushed the car’ and ‘The women left the party early’, and action sentences about formal or institutional groups that use singular noun phrases, such (...) as ‘The United States declared war on Japan on December 8th, 1941’ and ‘The Supreme Court ruled that segregation is unconstitutional in 1954 in Brown vs. Board of Education’? 3. Under what conditions does it make sense to speak of a group doing something together, and what, if anything, is a collective action? In this paper, I argue that a) understanding action sentences about groups does not commit us to the existence of group agents per se, but only to the existence of individual agents; b) there is no difference in this regard between sentences which attribute actions to informal groups on the one hand and institutional groups on the other; c) collective action can be both intentional and unintentional; d) any random group of agents each of whom does something is also a group which does something together; e) while there is a sense in which groups per se perform no primitive collective actions, and therefore no actions at all, f) there is a sensible extension of talk of actions to groups, though it should be treated strictly speaking, like talk of group agents, as a façon de parler, for g) the only agents per se are individuals and the only actions are theirs. -/-. (shrink)

continent. 1.2 (2011): 145-147. Here I accoutred myself in my new habiliments; and, having em- ployed the same precautions as before, retired from my lodging at a time least exposed to observation. It is unnecessary to des- cribe the particulars of my new equipage; suffice it to say, that one of my cares was to discolour my complexion, and give it the dun and sallow hue which is in most instances characteristic of the tribe to which I assumed to belong; (...) and that when my metamorphosis was finished, I could not, upon the strictest ex- amination, conceive that any one could have traced out the per- son of Caleb Williams in this new disguise. William Godwin Caleb Williams (352). Giorgio Agamben. Nudities . Trans. David Kishik and Stefan Pedatella. Stanford: Stanford University Press, 2011. 144 pp. | 10 illustrations. | ISBN: 9780804769501 | $16.95 A. The Protective Overcoat. The most pervasive, resilient, robust, sneaky, and significant concept in all of Giorgio Agamben’s essays is that of separation. This is not the same as alienation. Separation is more nostalgic, for Agamben valorizes an ancient world in which human society and its beings were not subject to such separation. He implies that these separations are damaging to human beings, crippling them at the very level of their identities. $4.99 B. The Handsome Gloves. Giorgio Agamben’s Nudities , like Profanations before it, employs a wide range of subjects in order to establish separation as a metaphor, in much the same way that interdisciplinary scholars have adopted Michel Foucault’s concepts in order to rethink societies and texts. The longest essay from Profanations, entitled “In Praise of Profanation,” laments humankind’s inability to profane as the result of what Walter Benjamin has called “the capitalist religion.” Likewise, “Nudity” adopts a pessimistic stance on the Christian theological tradition’s perverse asphyxiation of the unclothed body. $2.50 C. The Hoop Earrings. Religion separates humans from things by procuring for itself items as “sacred,” thus taking them out of common use. In this state, human beings are unable to play with them, unable to change their use-value. They become off-limits, museified. $1,499.00 D. The Uncomfortable Shoes. Biometrics polices identity, replacing meaningful metrics of identity. It is a deplorable situation that leaves human beings in danger of, and indeed already victims of, mass persecution. $111.75 E. The Prince Albert. One could characterize Giorgio Agamben’s desire to catalogue a history of ignorance as a recognition that human beings are separated from knowledge by language. Where then is the prophet, and how shall we be saved? $49.50 + tip F. The Corset. Franz Kafka’s character of Joseph K. has put himself on trial, as in Roman trials when the Kalumniator was marked with the letter K. The torture he undergoes is meant to elicit a confession of the truth. It is possible that Giorgio Agamben perceives his role as a philosopher to be confined to self-trial, and that with every passage he flays the unclothed page with prophetic intent. $27.00 G. The Derby. Giorgio Agamben himself tries to bridge various separations through exploratory play. He is not a performative writer semantically, but his exploratory style is rooted in the play spirit. His strategy of numbering points is almost comical, yet it is not misleading. It is play, after all, not ruse. He denudes with pecks, like carrion on a tattered corpse. $11.00 H. The Trousers. Although Giorgio Agamben is elsewhere concerned with the profanation of religion’s apparatuses, in essay nine he would like to consider what is consumed during days of inoperativity, how religion governs these, and how to account for our binges and purges. Inoperativity is inextricably bound to feasting, to the festival. $24.50 I. The Stylish Belt. The only essay in Nudities to contain photographs is the essay entitled, “Nudity.” All of these photographs project human bodies. $.01 I The aim here is not to tap into an original state prior to the separation but to comprehend and neutralize the apparatus that produced this separation. (66) II The contemporary is he who firmly holds his gaze on his own time so as to perceive not its light but rather its darkness. (13) III We can therefore only experience nudity as a denudation and a baring, never as a form and a stable possession. (65) IV Just as genius and talent originally distinct and even opposite—are nevertheless united in the work of the poet, so the work of creation and the work of salvation, inasmuch as they represent the two powers of a single God, remain in some way secretly conjoined. (6) V In our culture, the face-body relationship is marked by a fundamental asymmetry, in that our faces remain for the most part naked, while our bodies are normally covered. (88) VI Every man initiates a slanderous trial against himself. (21) VII The glorious body is not some other body, more agile and beautiful, more luminous and spiritual; it is the body itself, at the moment when inoperativity removes the spell from it and opens it up to a new possible common use. (103) VIII As Kleist understood so well, the relationship with a zone of nonknowledge is a dance. (114) IX The deactivation of this apparatus retroactively operates, therefore, as much on nature as on grace, as much on nudity as on clothing, liberating them from their theological signature. (90) X At any rate, whether festive inoperativity precedes religion or results from the profanation of its apparatuses, what is essential here is a dimension of praxis in which simple, quotidian human activities are neither negated nor abolished but suspended and rendered inoperative in order to be exhibited, as such, in a festive manner. (112) XI This is just how much [of] the land [the] surveyor is allowed to catch a glimpse. (36). (shrink)

This article raises two questions about Robert Myers and Claudine Verheggen's terrific book, Donald Davidson's Triangulation Argument: A Philosophical Inquiry. The first question, concerning the first part of the book, is whether, starting from the assumption that a solitary individual cannot have thought contents, we can show that adding another individual to the picture cannot resolve the problem. The second question, concerning the second part, is whether a more sophisticated, decision-theoretic, Humean about the pro-attitudes can respond to the objections to (...) the simple Humean view, and whether Davidson was not in fact just such a sophisticated decision-theoretic Humean. RÉSUMÉ: Cet article pose deux questions sur le formidable livre de Robert Myers et Claudine Verheggen, Donald Davidson's Triangulation Argument: A Philosophical Inquiry. La première question, qui concerne la première partie du livre, consiste à déterminer si, étant donné la supposition qu'un individu solitaire ne peut pas avoir de contenus mentaux, nous pouvons démontrer qu'ajouter un autre individu ne permet pas de résoudre le problème. La seconde question, qui concerne la deuxième partie du livre, est de savoir si un tenant d'une conception humienne des pro-attitudes plus sophistiquée, adhérant à la théorie de la décision, peut répondre aux objections formulées contre la simple conception humienne, et si Davidson n’était pas en fait un tenant de ce second type de conception humienne. (shrink)

© Ginn et al. 2016.The indexing methods currently used for serial femtosecond crystallography were originally developed for experiments in which crystals are rotated in the X-ray beam, providing significant three-dimensional information. On the other hand, shots from both X-ray free-electron lasers and serial synchrotron crystallography experiments are still images, in which the few three-dimensional data available arise only from the curvature of the Ewald sphere. Traditional synchrotron crystallography methods are thus less well suited to still image data processing. Here, a (...) new indexing method is presented with the aim of maximizing information use from a still image given the known unit-cell dimensions and space group. Efficacy for cubic, hexagonal and orthorhombic space groups is shown, and for those showing some evidence of diffraction the indexing rate ranged from 90% to 151%. Here, the indexing rate refers to the number of lattices indexed per image. (shrink)

Suppose that a physical duplicate of me, right down to the arrangements of subatomic particles, comes into existence at the time at which I finish this sentence. Suppose that it comes into existence by chance, or at least by a causal process entirely unconnected with me. It might be so situated that it, too, is seated in front of a computer, and finishes this paragraph and paper, or a corresponding one, just as I do. (i) Would it have the same (...) thoughts I do? (ii) Would it speak my language? (iii) Would my duplicate have any thoughts or (iv) speak any language at all? To fix the interpretation of these questions, I will take ‘thought’ to cover any mental state which has a representational content, where ‘representational content’ is intended to be neutral with respect to psychological mode. By 'psychological mode' I mean what distinguishes kinds of thoughts, such as belief, visual perceptual experience, desire, etc. Representational content, or thought content, as I will also say, determines the conditions under which a thought is true or false, veridical or non-veridical, or, more broadly, is satisfied or fails to be satisfied, independently of relativization to circumstances, possible worlds, or the like. Beliefs, desires, hopes, intentions, and perceptual experiences will all count as thoughts on this usage. The question whether one person has the same (type of) thought as another is the question whether both have a mental state with the same representational content in the same psychological mode. I will not count epistemic verbs, however, as picking out or expressing a (pure) psychological mode. Thus, although knowing that the time is ripe, seeing that there is a goldfinch in the garden, and remembering that my wife’s birthday is next Tuesday are all thoughts, they do not pick out the thoughts by using a verb that expresses a psychological mode. Therefore knowing, seeing or remembering the same things is not a requirement on having the same thoughts.. (shrink)

I have argued that a strong kind of physicalism based on the strict implication thesis can consistently reject both eliminativism and reductionism (in any nontrivial sense). This piece defends that position against objections from Andrew Melnyk, who claims that either my formulation doesn't entail physicalism, or it must be interpreted in such a way that the mental is after all reducible to the physical. His alternatives depend on two interesting assumptions. I argue that both are mistaken, thereby, making this kind (...) of nonreductive physicalism clearer and more clearly defensible. (shrink)

One of the curious things about Homeric studies is the way in which, although opinions in this field fluctuate violently, from time to time certain among them tend to become crystallized for no particular reason and are then accepted as something approaching orthodoxy. It is to try to delay such a crystallization, if it is not already too late, that I direct this brief coup d'ail at some current opinions on whether Homer—for the sake of clarity I apply this name (...) in the first instance to the monumental composer of the Iliad—used the aid of writing, and in general at the value of comparative inferences based on the heroic poetry of modern Yugoslavia. (shrink)

During the excavations of 1924–5 at Karanis a papyrus of the second or early third century A.D. was discovered, and subsequently published by J. G. Winter , which under its single column has a subscribed title which should almost certainly be restored as ‘Alcidamas, On Homer’. The first fourteen lines of the papyrus give most of the story of Homer's death and the riddle that caused it, which is common to all the extant Lives of Homer; the remainder is a (...) general eulogy of Homer and a profession of transmitting his works to posterity. The interest of the discovery lies in the knowledge that it gives of a hitherto unrecorded work by Alcidamas, the rhetorician and contemporary of Isocrates, and the new fuel that it provides for an old controversy about the origins of the work known as the Certamen. The first part of this article aims at both re-examining the value of the papyrus and reopening some of the old questions on the Certamen. (shrink)

It seems very commonly agreed that Sappho's wedding-songs display none of the ritual obscenity so frequent in the genre. Thus D. L. Page wrote of fr. i ioa that ‘There is no trace here or elsewhere in Sappho of that ribaldry which was characteristic of the songs recited at this and other stages of Greek wedding-ceremonies’. Similarly Sir Maurice Bowra asserted of fr. 111 that it is ‘neither bawdy nor exalted, but playful. If the humour is a bit primitive, that (...) is due to tradition, which expected jokes at this level’. On the next page he writes of the songs sung outside the bridal chamber, as distinct from those sung in the procession thither, that ‘Here too Sappho seems to avoid bawdry but is not averse from rather elementary jokes’. (shrink)

It seems very commonly agreed that Sappho's wedding-songs display none of the ritual obscenity so frequent in the genre. Thus D. L. Page wrote of fr. i ioa that ‘There is no trace here or elsewhere in Sappho of that ribaldry which was characteristic of the songs recited at this and other stages of Greek wedding-ceremonies’. Similarly Sir Maurice Bowra asserted of fr. 111 that it is ‘neither bawdy nor exalted, but playful. If the humour is a bit primitive, that (...) is due to tradition, which expected jokes at this level’. On the next page he writes of the songs sung outside the bridal chamber, as distinct from those sung in the procession thither, that ‘Here too Sappho seems to avoid bawdry but is not averse from rather elementary jokes’. (shrink)

One of the curious things about Homeric studies is the way in which, although opinions in this field fluctuate violently, from time to time certain among them tend to become crystallized for no particular reason and are then accepted as something approaching orthodoxy. It is to try to delay such a crystallization, if it is not already too late, that I direct this brief coup d'ail at some current opinions on whether Homer—for the sake of clarity I apply this name (...) in the first instance to the monumental composer of the Iliad—used the aid of writing, and in general at the value of comparative inferences based on the heroic poetry of modern Yugoslavia. (shrink)

During the excavations of 1924–5 at Karanis a papyrus of the second or early third century A.D. was discovered, and subsequently published by J. G. Winter, which under its single column has a subscribed title which should almost certainly be restored as ‘Alcidamas, On Homer’. The first fourteen lines of the papyrus give most of the story of Homer's death and the riddle that caused it, which is common to all the extant Lives of Homer; the remainder is a general (...) eulogy of Homer and a profession of transmitting his works to posterity. The interest of the discovery lies in the knowledge that it gives of a hitherto unrecorded work by Alcidamas, the rhetorician and contemporary of Isocrates, and the new fuel that it provides for an old controversy about the origins of the work known as the Certamen. The first part of this article aims at both re-examining the value of the papyrus and reopening some of the old questions on the Certamen. (shrink)